Article
Modelling idiopathic Parkinson disease as a complex illness can inform incidence rate in healthy adults: the PR EDIGT score.
The European journal of neuroscience - 1 Jan 2017
Schlossmacher Michael G, Tomlinson Julianna J, Santos Goncalo, Shutinoski Bojan, Brown Earl G, Manuel Douglas, Mestre Tiago
Abstract excerpt
Fifty-five years after the concept of dopamine replacement therapy was introduced, Parkinson disease (PD) remains an incurable neurological disorder. To date, no disease-modifying therapeutic has been approved. The inability to predict PD incidence risk in healthy adults is seen as a limitation in drug development, because by the time of clinical diagnosis ≥ 60% of dopamine neurons have been lost. We have...
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