Article

Prediction of bacterial protein-compound interactions with only positive samples

2025-07-23

Abstract excerpt

Prediction of Compound-Protein Interactions (CPI) in bacteria is crucial to advance various pharmaceutical and chemical engineering fields, including bio-catalysis, drug discovery, and industrial processing. However, current CPI models cannot be applied for bacterial CPI prediction due to the lack of curated negative interaction samples. This paper introduces a novel Positive-Unlabeled (PU) learning framework, nam...

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Literature Corpus work: 41403cdf-59cf-572c-bf56-2bf85b5be88a
DOI: 10.1101/2025.07.18.665643

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