Article

The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors

2024-08-19

Abstract excerpt

Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma that may be seen in patients with neurofibromatosis type 1 (NF1) or occur sporadically. While surgery is the primary treatment for localized MPNST with a 61.9% overall survival rate, metastatic disease is often fatal due to resistance to systemic therapies which underscores the urgent need for effective treatments. MPNSTs frequently har...

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Literature Corpus work: 412c1f9a-aa19-51a8-ab5f-68b4ef1f24e4
DOI: 10.1101/2024.08.17.607802

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