Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterisation of the pathophysiology of neuropathy and sensory dysfunction in a mouse model of recessive dystrophic epidermolysis bullosa.

Pain - 1 Oct 2022

Schmidt Daniela, Díaz Paula, Muñoz Daniela, Espinoza Fernanda, Nystrom Alexander, Fuentes Ignacia, Ezquer Marcelo, Bennett David L, Calvo Margarita

Abstract excerpt

ABSTRACT: Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genetic condition in which mutations in the type VII collagen gene ( COL7A1 ) lead to decreased expression of this anchoring protein of the skin, causing the loss of stability at the dermo-epidermal junction. Most patients with RDEB experience neuropathic pain and itch due to the development of a small fibre neuropathy, characterised by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagen Type VII
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermolysis Bullosa Dystrophica

Share to Mutation

Source

Identifiers

PMID: 35311752
DOI: 10.1097/j.pain.0000000000002599

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterisation of the pathophysiology of neuropathy and sensory dysfunction in a mouse model of recessive dystrophic epidermolysis bullosa.PMID 35311752Read ↗

Pathomechanisms of Altered Wound Healing in Recessive Dystrophic Epidermolysis Bullosa.Semantic proximity Read ↗

Targeted inactivation of the type VII collagen gene (Col7a1) in mice results in severe blistering phenotype: a model for recessive dystrophic epidermolysis bullosa.Semantic proximity Read ↗

Rat Model for Dominant Dystrophic Epidermolysis Bullosa: Glycine Substitution Reduces Collagen VII Stability and Shows Gene-Dosage EffectSemantic proximity Read ↗

Pain in recessive dystrophic epidermolysis bullosa (RDEB): findings of the Prospective Epidermolysis Bullosa Longitudinal Evaluation Study (PEBLES)Semantic proximity Read ↗

Immunological mechanisms underlying progression of chronic wounds in recessive dystrophic epidermolysis bullosaSemantic proximity Read ↗

Sensory profiling in classical Ehlers-Danlos syndrome: a case-control study revealing pain characteristics, somatosensory changes, and impaired pain modulationSemantic proximity Read ↗

Characterization of small fiber neuropathy in hypermobile Ehlers Danlos SyndromeSemantic proximity Read ↗

The COL6A5-p.Glu2272* mutation induces chronic itch in miceSemantic proximity Read ↗

Pain-related behaviors and abnormal cutaneous innervation in a murine model of classical Ehlers-Danlos syndrome.Semantic proximity Read ↗

The COL6A5-p.Glu2272* mutation induces chronic itch in mice.Semantic proximity Read ↗

Two independent mouse lines carrying the Nav1.7 I228M gain-of-function variant display dorsal root ganglion neuron hyperexcitability but a minimal pain phenotype.Semantic proximity Read ↗

A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.