Article

Sex and Disease Regulate MHC I Expression in Human Lung Epithelial Cells

2024-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Major histocompatibility complex class I (MHC I) molecules present endogenous peptides to CD8+ T-cells for immunosurveillance of infections and cancers. Recent studies revealed unexpected heterogeneity in MHC I expression among cells of different lineages. While respiratory diseases rank among the leading causes of mortality, studies in mice showed that lung epithelial cells (LECs) express lower...

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Literature Corpus work: 40af1190-bcd6-5ac3-874b-faee2200ffa4
DOI: 10.1101/2024.06.20.599895

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