Article
Recombinant activated factor VII and tranexamic acid are haemostatically effective during major surgery in factor XI-deficient patients with inhibitor antibodies.
Thrombosis and haemostasis - 1 Sept 2009
Livnat Tami, Tamarin Ilia, Mor Yoram, Winckler Harry, Horowitz Zeev, Korianski Yoseph, Bar-Zakay Barak, Seligsohn Uri, Salomon Ophira
Abstract excerpt
One-third of patients with severe factor XI (FXI) deficiency caused by homozygosity for null alleles develop inhibitor antibodies following exposure to plasma. Haemostasis during surgery is achievable in such patients by recombinant activated factor VII (rFVIIa) at doses used in haemophilia A patients with an inhibitor to FVIII. However, thrombosis has occurred in three of 12 such patients. In this study we...
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