Article

FLASH or flare: variable intestinal toxicity results in a mouse model following proton pencil beam scanning irradiation on a clinical superconducting synchrocyclotron

2025-09-20

Abstract excerpt

<h4>Background and aims</h4> Ultra-high dose rate (FLASH) irradiation is a promising technique to reduce radiation-induced normal tissue toxicities while preserving antitumor efficacy. We evaluated the feasibility and intestinal sparing potential of FLASH irradiation using a clinical synchrocyclotron-based proton therapy system generating a pulsed beam. <h4>Material and methods</h4> C57BL/6J mice received abdomi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 40079a52-cb08-5053-8ab0-9add4e75b6f4
DOI: 10.1101/2025.09.17.676536

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FLASH or flare: variable intestinal toxicity results in a mouse model following proton pencil beam scanning irradiation on a clinical superconducting synchrocyclotronDOI 10.1101/2025.09.17.676536Read

Independent Reproduction of the FLASH Effect on the Gastrointestinal Tract: A Multi-Institutional Comparative StudySemantic proximity Read

Leveraging the Immune Response from LIFE Biomaterial and Photon-Flash in Pre-Clinical Pancreatic Cancer TreatmentSemantic proximity Read

Transcriptome of the murine duodenum during recovery after a lethal dose of total body irradiationSemantic proximity Read

FLASH radiotherapy using high-energy X-rays: validation of the FLASH effect triggered by a compact single high-energy X-ray source deviceSemantic proximity Read

Localized FLASH Radiotherapy Reduces Long-Term Skin and Muscle Damage While Preserving Systemic HomeostasisSemantic proximity Read

First demonstration of the FLASH effect with ultrahigh dose-rate high-energy X-raysSemantic proximity Read

Increased Relative Biological Effectiveness of Orthovoltage X-rays Compared to γ-rays in Preclinical IrradiationSemantic proximity Read

<em>Drosophila melanogaster</em> as a Model of Gastrointestinal Radiation Injury Studies: Conserved Mechanisms, Experimental Approaches, and Countermeasure DiscoverySemantic proximity Read

FLASH Radiotherapy: Mechanisms, Preclinical Evidence, and Clinical PotentialSemantic proximity Read

Discovery of a radiation countermeasure therapeutic for intestinal injury enabled by human organ chips combined with AISemantic proximity Read

Temporary knockdown of p53 during focal limb irradiation increases the development of sarcomasSemantic proximity Read