Article

Integrating theory and machine learning to reveal determinants of plasmid copy number

2025-10-23

Abstract excerpt

Plasmids are extrachromosomal mobile genetic elements whose copy numbers (PCNs) critically influence microbial evolution, antibiotic resistance and pathogenicity. Despite their importance and immense diversity, the ecological, evolutionary and molecular factors determining PCN remain poorly understood. Here, we present a theoretical model to explain the empirical power-law relationship between plasmid size and cop...

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Literature Corpus work: 4000ba20-00c5-5b9f-913b-458744a70e00
DOI: 10.1101/2025.10.23.684078

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