Article
Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.
Scientific reports - 10 May 2016
Patmanathan Sathya Narayanan, Johnson Steven P, Lai Sook Ling, Panja Bernam Suthashini, Lopes Victor, Wei Wenbin, Ibrahim Maha Hafez, Torta Federico, Narayanaswamy Pradeep, Wenk Markus R, Herr Deron R, Murray Paul G, Yap Lee Fah, Paterson Ian C
Abstract excerpt
Oral squamous cell carcinoma (OSCC) is a lethal disease with a 5-year mortality rate of around 50%. Molecular targeted therapies are not in routine use and novel therapeutic targets are required. Our previous microarray data indicated sphingosine 1-phosphate (S1P) metabolism and signalling was deregulated in OSCC. In this study, we have investigated the contribution of S1P signalling to the pathogenesis of OSCC....
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