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Restriction site associated DNA sequencing for tumour mutation burden estimation and mutation signature analysis

2023-07-29

Abstract excerpt

Genome-wide measures of genetic disruption such as tumour mutation burden (TMB) and mutation signatures are emerging as useful biomarkers to stratify patients for treatment. Clinicians commonly use cancer gene panels for tumour mutation burden estimation, and whole genome sequencing is the gold standard for mutation signature analysis. However, the accuracy and cost associated with these assays limits their utilit...

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Identifiers and source

Literature Corpus work
6c36e80a-db98-56ac-a265-f00559ade81a
DOI
10.1101/2023.07.27.550611
Open publication

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Restriction site associated DNA sequencing for tumour mutation burden estimation and mutation signature analysisDOI 10.1101/2023.07.27.550611
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