Article

Durable Control of HIV-1 Using a <i>Staphylococcus aureus</i> Cas9-Expressing Lentivirus Co-Targeting Viral Latency and Host Susceptibility

2020-08-10

Abstract excerpt

<h4>ABSTRACT</h4> CRISPR/Cas9 gene editing has the potential to revolutionize the clinical management of HIV-1 infection, and may eliminate the need for antiretroviral therapy (ART). Current gene therapies attempt to either excise HIV-1 provirus or target HIV-1 entry receptors to prevent infection of new cells. Using a viral dynamic model, we determined that combining these two interventions, in the presence or a...

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Literature Corpus work: 3fbfd6ff-5b9c-5475-9124-a29247a42c09
DOI: 10.1101/2020.08.10.243329

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