Article

Ketolysis is Required for the Proper Development and Function of the Somatosensory Nervous System

2023-01-13

Abstract excerpt

Ketogenic diets are emerging as protective interventions in preclinical and clinical models of somatosensory nervous system disorders. Additionally, dysregulation of succinyl-CoA 3-oxoacid CoA-transferase 1 (SCOT, encoded by Oxct1 ), the fate-committing enzyme in mitochondrial ketolysis, has recently been described in Friedreich’s ataxia and amyotrophic lateral sclerosis. However, the contribution of ketone metab...

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Literature Corpus work: 3f6c2ff6-3252-50ac-8ce4-f8a64bcb1e84
DOI: 10.1101/2023.01.11.523492

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