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Article

A ketogenic diet rescues the murine succinic semialdehyde dehydrogenase deficient phenotype.

Experimental neurology - 1 Apr 2008

Nylen Kirk, Velazquez Jose Luis Perez, Likhodii Sergei S, Cortez Miguel A, Shen Lily, Leshchenko Yevgen, Adeli Khosrow, Gibson K Michael, Burnham W M, Snead O Carter

Abstract excerpt

Succinic semialdehyde dehydrogenase (SSADH) deficiency is a heritable disorder of GABA degradation characterized by ataxia, psychomotor retardation and seizures. To date, there is no effective treatment for SSADH deficiency. We tested the hypothesis that a ketogenic diet (KD) would improve outcome in an animal model of SSADH deficiency, the SSADH knockout mouse (Aldh5a1-/-). Using a 4:1 ratio of fat to combined...

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Identifiers

PMID: 18199435
DOI: 10.1016/j.expneurol.2007.11.015
PMCID: PMC2362105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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