Article

Recent Advances of Wee1 Inhibitors and Statins in Gynecologic Cancers with p53 Mutations

2021-06-07

Abstract excerpt

p53 is among the most frequently mutated tumor suppressor genes given its prevalence in >50% of all human cancers, including high grade serous endometrial cancers and ovarian cancers. In addition to loss of tumor suppression function, many mutated p53 (Mutp53) proteins acquire gain-of-function (GOF) activities as oncogenes to promote cancer progression, which manifest through aberrant expression of p53. As we h...

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Literature Corpus work: 3f41bc77-aae4-5de2-a9ba-0fd985f7d8da
DOI: 10.20944/preprints202106.0158.v1

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