Article

Mutational analyses reveal PLP-independent functions at PipY, the cyanobacterial paradigm for pyridoxal-phosphate binding proteins

2025-12-30

Abstract excerpt

Pyridoxal-phosphate binding proteins (PLPBP) are involved in the homeostasis of B 6 vitamers and amino/keto acids, share a high degree of sequence conservation and are represented in all three domains of life. Despite the obligate presence of the catalyst cofactor PLP, attempts to show enzymatic activity have been unsuccessful. Instead, evidence of RNA binding activity has been provided for several members of the...

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Literature Corpus work: 3f246b55-4d8b-5b26-a808-bccd106cc569
DOI: 10.64898/2025.12.29.696868

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