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Biphasic Regulation of Epithelial Antimicrobial Peptides during <em>Candida albicans</em> Vaginal Infection: Distinct Contributions of NLRP3/IL-1β and IL-17RA Pathways to β-Defensin-1 and -3 Expression

2026-02-10

Abstract excerpt

Candida albicans is the primary agent of acute vulvovaginal candidiasis(VVC) and its recurrent form(RVVC). Local innate immunity contributes to both defense and pathogenesis during vaginal Candida infection, where epithelial β-defensins(BD) constitute key components of the mucosal barrier. We previously reported that epithelial BD-1 expression is dynamically modulated during murine and human vaginitis, revealing s...

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Literature Corpus work: 3f0f65c5-8543-5c74-aff4-428b80151987
DOI: 10.20944/preprints202602.0806.v1

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Biphasic Regulation of Epithelial Antimicrobial Peptides during <em>Candida albicans</em> Vaginal Infection: Distinct Contributions of NLRP3/IL-1β and IL-17RA Pathways to β-Defensin-1 and -3 ExpressionDOI 10.20944/preprints202602.0806.v1Read

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