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Tubulin-Targeted Agents Including Docetaxel and Cabazitaxel

1 Jan 2013

Abstract excerpt

Microtubules are dynamic filamentous cytoskeletal proteins that are responsible for cellular integrity and architecture, mitosis, intracellular transport, cell signaling, and gene expression. Tubulin exists in the cell as dimers of α and β subunits, which complexes with a variety of regulatory proteins. There is a dynamic equilibrium between free and polymerized tubulin causing a state called "dynamic...

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PMID: 23337758
DOI: 10.1097/ppo.0b013e3182828d38

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