Article

Metformin's Impact on Follistatin and Oxyntomodulin in PCOS, and Comorbidities: Secondary Analysis of a Double-Blind RCT

2023-07-06

Abstract excerpt

<h4>Background: </h4> Abnormal secretion of incretins, particularly Glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and oxyntomodulin (OXM), have been observed in individuals with Type 2 diabetes mellitus and PCOS. OXM plays a crucial role in metabolism, including reducing food intake and improving insulin secretion to decrease liver fat accumulation. Metformin, an insulin-sens...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e73281a-116b-5fbd-8d05-5fecb74d1c3b
DOI: 10.21203/rs.3.rs-2996959/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metformin's Impact on Follistatin and Oxyntomodulin in PCOS, and Comorbidities: Secondary Analysis of a Double-Blind RCTDOI 10.21203/rs.3.rs-2996959/v1Read

Metformin Effects on Follistatin and Oxyntomodulin Levels and Its Relationship With Polycystic Ovaries Syndrome and Associated Comorbidities: Secondary Analysis of Randomized Double-blind Clinical Study.Semantic proximity Read

Metformin pathwaysSemantic proximity Read

Effects of Metformin on Reproductive, Endocrine, and Metabolic Characteristics of Female Offspring in a Rat Model of Letrozole-induced Polycystic Ovarian Syndrome With Insulin ResistantSemantic proximity Read

Function and therapeutic potential of metformin in multiple diseasesSemantic proximity Read

Anti-tumor activity of metformin: from metabolic and epigenetic perspectivesSemantic proximity Read

Pharmacological Evaluation of Bergapten in High Fat Diet and Letrozole Induced Polycystic Ovarian Syndrome in Wistar RatsSemantic proximity Read

Metformin prevents oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome via activation of Nrf2-HO-1 pathwaySemantic proximity Read

Is Metformin a Perfect Drug? Updates in Pharmacokinetics and Pharmacodynamics.Semantic proximity Read

Metformin in Reproductive BiologySemantic proximity Read

Exploring the Therapeutic Potential of Natural Products on Polycystic Ovarian Syndrome (PCOS): A Mini Review of Lipid Profile, Blood Glucose, and Ovarian Histological ImprovementsSemantic proximity Read

[Metformin - new data for an "old", but efficient, safe and reliable antidiabetic drug].Semantic proximity Read

The effect of alfacalcidiol and metformin on phenotype manifestations in women with polycystic ovary syndrome - a preliminary study.Semantic proximity Read