Article

Lysophosphatidic acid induces the expression of angiogenic factors in human trophoblast cells –a way of understanding the etiology of PIH–

2015-01-01

Abstract excerpt

【目的】リゾフォスファチジン酸(LPA)は細胞膜受容体を介して多様な生理機能に関与する脂質メディエーターであり，主に酵素オートタキシン(ATX)により産生される。妊娠高血圧症候群(PIH)では，正常妊娠と比較して胎盤におけるATX産生が有意に低下することを我々は過去に報告した。本研究ではATX産生低下の意義を調べるため，LPA受容体の一つであるLPAR3に着目した。LPAR3は，その欠損マウスにおいて着床遅延が生じることが報告されており，生殖分野への関与が示唆されている。我々は，LPAR3の胎盤における発現パターンを検討した。また絨毛細胞由来株にLPAR3を強制発現させた上でアゴニストによる刺激を行い，血管新生関連因子の発現を検討した。【方法】本研究は当院研究倫理委員会の承認の下，患者の同意を得て行った。免疫染色法によりヒト胎盤におけるATX，LPAR3の発現分布を確認した。絨毛細胞由来株HTR-8/SVneoにLPAR3...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e43e6a5-b513-5f2a-907a-9598e73d6fca
DOI: 10.3192/jsirib.30.22

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lysophosphatidic acid induces the expression of angiogenic factors in human trophoblast cells –a way of understanding the etiology of PIH–DOI 10.3192/jsirib.30.22Read

Trophoblast Cell Function in the Antiphospholipid SyndromeSemantic proximity Read

Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Trophoblast FunctionsSemantic proximity Read

Progress in the understanding of the etiology and predictability of fetal growth restrictionSemantic proximity Read

Platelet-derived factors dysregulate placental sphingosine-1-phosphate receptor 2 in human trophoblastsSemantic proximity Read

Beyond pregnancy: modulation of trophoblast invasion and its consequences for fetal growth and long-term children's healthSemantic proximity Read

Lysophosphatidic acid-triggered pathways promote the acquisition of trophoblast endovascular phenotype in vitro.Semantic proximity Read

Understanding and management of gestational trophoblastic diseaseSemantic proximity Read

LPS-induced PTGS2 manipulates the inflammatory response through trophoblast invasion in preeclampsia via NF-κB pathwaySemantic proximity Read

Maternal platelet-derived factors induce trophoblastic LAIR2 expression to promote trophoblast invasion and inhibit platelet activation at the fetal-maternal interfaceSemantic proximity Read

Involvement of MAPK Signalling in Human Villous Trophoblast DifferentiationSemantic proximity Read

Circulating trophoblast in maternal bloodSemantic proximity Read

Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiationSemantic proximity Read

Lysophosphatidic acid induces the expression of angiogenic factors in human &lt;sub&gt;trophoblast cells &lt;/sub&gt;&lt;b&gt;–&lt;/b&gt;&lt;sub&gt;a way of understanding the etiology of PIH&lt;/sub&gt;&lt;b&gt;–&lt;/b&gt;

Abstract excerpt

Topics

Identifiers and source

Related research

Lysophosphatidic acid induces the expression of angiogenic factors in human <sub>trophoblast cells </sub><b>–</b><sub>a way of understanding the etiology of PIH</sub><b>–</b>