Maternal platelet-derived factors induce trophoblastic LAIR2 expression to promote trophoblast invasion and inhibit platelet activation at the fetal-maternal interface

Abstract excerpt

BACKGROUND: During human placentation, extravillous trophoblasts (EVTs) arising from cell column trophoblasts (CCTs) invade the highly differentiated uterine mucosa, called decidua, where they erode blood vessels and replace vascular endothelial cells. Maternal platelets have been detected in intercellular gaps of CCTs, but their physiological role remains unclear. OBJECTIVES: This study aimed to elucidate the...