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Article

Lysophosphatidic acid-triggered pathways promote the acquisition of trophoblast endovascular phenotype in vitro.

Journal of cellular biochemistry - 1 Jan 2018

Beltrame Jimena S, Sordelli Micaela S, Cañumil Vanesa A, Franchi Ana M, Ribeiro María L

Abstract excerpt

Successful implantation and placentation requires that extravillous cytotrophoblast acquires an endovascular phenotype and remodels uterine spiral arteries. Defects in this mechanism correlate with severe obstetric complications as implantation failure and preeclampsia. Lysophosphatidic acid (LPA) participates in embryo implantation and contributes to vascular physiology in different biological systems. However,...

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Identifiers

PMID: 28657680
DOI: 10.1002/jcb.26239

Genes

LPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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