Article

Kleine Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci

2021-01-16

Abstract excerpt

Kleine-Levin Syndrome (KLS) is a rare disorder characterized by severe episodic hypersomnia, with cognitive impairment accompanied by apathy or disinhibition. Pathophysiology is unknown, although imaging studies indicate decreased activity in hypothalamic/thalamic areas during episodes. Familial occurrence is increased, and risk is associated with reports of a difficult birth. We conducted a worldwide case-control...

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Literature Corpus work: 3e33d4a7-070a-5a89-918e-66ada34db293
DOI: 10.1101/2021.01.08.20249006

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