Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci.

doi:10.1073/pnas.2005753118

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Article

Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci.

Proceedings of the National Academy of Sciences of the United States of America - 23 Mar 2021

Ambati Aditya, Hillary Ryan, Leu-Semenescu Smaranda, Ollila Hanna M, Lin Ling, During Emmanuel H, Farber Neal, Rico Thomas J, Faraco Juliette, Leary Eileen, Goldstein-Piekarski Andrea N, Huang Yu-Shu, Han Fang, Sivan Yakov, Lecendreux Michel, Dodet Pauline, Honda Makoto, Gadoth Natan, Nevsimalova Sona, Pizza Fabio, Kanbayashi Takashi, Peraita-Adrados Rosa, Leschziner Guy D, Hasan Rosa, Canellas Francesca, Kume Kazuhiko, Daniilidou Makrina, Bourgin Patrice, Rye David, Vicario José L, Hogl Birgit, Hong Seung Chul, Plazzi Guiseppe, Mayer Geert, Landtblom Anne Marie, Dauvilliers Yves, Arnulf Isabelle, Mignot Emmanuel Jean-Marie

Abstract excerpt

Kleine-Levin syndrome (KLS) is a rare disorder characterized by severe episodic hypersomnia, with cognitive impairment accompanied by apathy or disinhibition. Pathophysiology is unknown, although imaging studies indicate decreased activity in hypothalamic/thalamic areas during episodes. Familial occurrence is increased, and risk is associated with reports of a difficult birth. We conducted a worldwide...

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PMID: 33737391
DOI: 10.1073/pnas.2005753118
PMCID: PMC7999876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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