Article

Cryptic genetic variations of alanine:glyoxylate aminotransferase shape its fitness and dynamics

2021-05-25

Abstract excerpt

Genetic variations expand the conformational landscape of proteins and may underlie cryptic properties that promote environmental adaptability. However, they can also represent modifying factors for disease susceptibility, by changing frustrated regions that in turn affect protein overall intracellular fitness. In this dichotomy between conservation and innovation, understanding at structural level how genetic var...

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Literature Corpus work: 3d62fd04-2c37-56cc-8ee4-9e41b166b717
DOI: 10.1101/2021.05.24.445519

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