Article
Structural Capacitance in Protein Evolution and Human Diseases.
Journal of molecular biology - 14 Sept 2018
Li Chen, Clark Liah V T, Zhang Rory, Porebski Benjamin T, McCoey Julia M, Borg Natalie A, Webb Geoffrey I, Kass Itamar, Buckle Malcolm, Song Jiangning, Woolfson Adrian, Buckle Ashley M
Abstract excerpt
Canonical mechanisms of protein evolution include the duplication and diversification of pre-existing folds through genetic alterations that include point mutations, insertions, deletions, and copy number amplifications, as well as post-translational modifications that modify processes such as folding efficiency and cellular localization. Following a survey of the human mutation database, we have identified an...
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