Article

Explainable machine learning relates histological to genomic pathology

2026-08-09

Abstract excerpt

<h4>Background & Aims</h4> Haematoxylin and eosin (H&E) staining remains the diagnostic gold standard for solid cancers, including hepatocellular carcinoma, and is increasingly complemented by genomic profiling for precision medicine. Inferring genomic alterations directly from H&E images could streamline testing, but heterogeneity and biases in human training data limit interpretation of genotype-phenotype assoc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ced39ef-1b66-5dde-8985-32fb4348a9f3
DOI: 10.64898/2026.08.03.742582

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Explainable machine learning relates histological to genomic pathologyDOI 10.64898/2026.08.03.742582Read

Pan-cancer computational histopathology reveals mutations, tumor composition and prognosisSemantic proximity Read

Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis.Semantic proximity Read

Pan-cancer image-based detection of clinically actionable genetic alterations.Semantic proximity Read

GenoGlyph: Pan-cancer genomic mutation inference and risk stratification from diagnostic histopathology slidesSemantic proximity Read

Predicting Mutational Status of Driver and Suppressor Genes Directly from Histopathology With Deep Learning: A Systematic Study Across 23 Solid Tumor TypesSemantic proximity Read

Mutational landscape of a chemically-induced mouse model of liver cancerSemantic proximity Read

Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesisSemantic proximity Read

Nuclear Morphology Tracks Molecular Class Unevenly Across Four CancersSemantic proximity Read

Buyer Beware: confounding factors and biases abound when predicting omics-based biomarkers from histological imagesSemantic proximity Read

Integrated histopathologic modeling of detailed tumor subtypes and actionable biomarkersSemantic proximity Read

IHGAMP: Pan-cancer HRD prediction from routine H&E whole-slide images using foundation modelsSemantic proximity Read

Mutational landscape of a chemically-induced mouse model of liver cancer.Semantic proximity Read