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Article

Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration.

Nature communications - 25 Oct 2019

Menon Madhvi, Mohammadi Shahin, Davila-Velderrain Jose, Goods Brittany A, Cadwell Tanina D, Xing Yu, Stemmer-Rachamimov Anat, Shalek Alex K, Love John Christopher, Kellis Manolis, Hafler Brian P

Abstract excerpt

Genome-wide association studies (GWAS) have identified genetic variants associated with age-related macular degeneration (AMD), one of the leading causes of blindness in the elderly. However, it has been challenging to identify the cell types associated with AMD given the genetic complexity of the disease. Here we perform massively parallel single-cell RNA sequencing (scRNA-seq) of human retinas using two...

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Identifiers

PMID: 31653841
DOI: 10.1038/s41467-019-12780-8
PMCID: PMC6814749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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