Back to search

Article

Infusion reactions to adeno‐associated virus (AAV)-based gene therapy: Mechanisms, diagnostics, treatment and review of the literature

2023-07-12

Abstract excerpt

The use of adeno-associated virus (AAV) vectors in gene therapy has demonstrated great potential in treating genetic disorders. However, infusion-associated reactions (IARs) pose a significant challenge to the safety and efficacy of AAV-based gene therapy. This review provides a comprehensive summary of the current understanding of IARs to AAV therapy, including their underlying mechanisms, clinical presentation,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3c8f7925-1617-517f-ab9a-4b7d777841c8
DOI
10.22541/au.168914712.20763806/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Infusion reactions to adeno‐associated virus (AAV)-based gene therapy: Mechanisms, diagnostics, treatment and review of the literatureDOI 10.22541/au.168914712.20763806/v1
Understanding and Tackling Immune Responses to Adeno-Associated Viral VectorsSemantic proximity
Adeno-associated virus therapies: Pioneering solutions for human genetic diseasesSemantic proximity
Immunogenicity of Recombinant Adeno-Associated Virus (AAV) Vectors for Gene TransferSemantic proximity
Challenges Posed by Immune Responses to AAV Vectors: Addressing Root CausesSemantic proximity
AAV vector manufacturing process design and scalability - Bending the trajectory to address vector-associated immunotoxicitiesSemantic proximity
AAV-Based Gene Therapy: Opportunities, Risks, and Scale-Up StrategiesSemantic proximity
Considerations for Preclinical Safety Assessment of Adeno-Associated Virus Gene Therapy ProductsSemantic proximity
Adeno-Associated Virus Gene Therapy for Liver DiseaseSemantic proximity
Evading and overcoming AAV neutralization in gene therapySemantic proximity
Development challenges associated with rAAV-based gene therapiesSemantic proximity
Current clinical applications of AAV-mediated gene therapySemantic proximity
AAV-Mediated Gene Therapy for Research and Therapeutic PurposesSemantic proximity
Select a neighboring publication to make it the new centre.