Hybrid Silica-Coated PLGA Nanoparticles for Enhanced Enzyme-Based Therapeutics

Abstract excerpt

Some cancer cells rely heavily on non-essential biomolecules for survival, growth, and proliferation. Enzyme based therapeutics can eliminate these biomolecules, thus specifically targeting neoplastic cells; however, enzyme therapeutics are susceptible to immune clearance, exhibit short half-lives, and require frequent administration. Encapsulation of therapeutic cargo within biocompatible and biodegradable poly(l...

Topics

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• Acute Lymphoblastic Leukemia research
• Amyotrophic Lateral Sclerosis
• Antioxidants
• ATP Synthase and ATPases Research
• CAR-T cell therapy research
• Enzyme function and inhibition
• Metal complexes synthesis and properties
• Microvessels

Identifiers and source

Literature Corpus work

3c47e5ee-c4ff-5ea5-9db3-726bd22fd38a

DOI

10.20944/preprints202212.0013.v1