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Article

SOD1 nanozyme with reduced toxicity and MPS accumulation.

Journal of controlled release : official journal of the Controlled Release Society - 10 Jun 2016

Jiang Yuhang, Arounleut Phonepasong, Rheiner Steven, Bae Younsoo, Kabanov Alexander V, Milligan Carol, Manickam Devika S

Abstract excerpt

We previously developed a "cage"-like nano-formulation (nanozyme) for copper/Zinc superoxide dismutase (SOD1) by polyion condensation with a conventional block copolymer poly(ethylene glycol)-b-poly(L-lysine) (PEG-PLL) followed by chemical cross-linking. Herein we report a new SOD1 nanozyme based on PEG-b-poly(aspartate diethyltriamine) (PEG-PAsp(DET), or PEG-DET for short) engineered for chronic dosing. This new...

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Identifiers

PMID: 26928528
DOI: 10.1016/j.jconrel.2016.02.038

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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