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TP53 or CDKN2A/B covariation in ALK/RET/ROS1-rearranged NSCLC is associated with a high TMB, tumor immunosuppressive microenvironment and poor prognosis

2023-04-24

Abstract excerpt

<h4>Introduction: </h4> ALK-rearranged lung adenocarcinomas with TP53 mutations have more unstable genomic features, poorer ALK-TKI efficacy and a worse prognosis than ALK-rearranged lung adenocarcinomas with wild-type TP53. Here, we examine the gene variations that co-occur with ALK/RET/ROS1 rearrangements in NSCLC and the corresponding tumor immune microenvironment, as well as their association with prognosis....

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Literature Corpus work
3c17ee9b-c09c-57bd-a762-c61bb8b9caae
DOI
10.21203/rs.3.rs-2837365/v1
Open publication

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TP53 or CDKN2A/B covariation in ALK/RET/ROS1-rearranged NSCLC is associated with a high TMB, tumor immunosuppressive microenvironment and poor prognosisDOI 10.21203/rs.3.rs-2837365/v1
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