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Article

TP53 or CDKN2A/B covariation in ALK/RET/ROS1-rearranged NSCLC is associated with a high TMB, tumor immunosuppressive microenvironment and poor prognosis.

Journal of cancer research and clinical oncology - 1 Sept 2023

Jiang Bin, Hu Liwen, Dong Daling, Guo Zixin, Wei Wei, Wang Chao, Shao Weikang, Ma Ting, Chen Yanhui, Li Qingyun, Hu Weidong

Abstract excerpt

INTRODUCTION: ALK-rearranged lung adenocarcinomas with TP53 mutations have more unstable genomic features, poorer ALK-TKI efficacy and a worse prognosis than ALK-rearranged lung adenocarcinomas with wild-type TP53. Here, we examine the gene variations that co-occur with ALK/RET/ROS1 rearrangements in NSCLC and the corresponding tumor immune microenvironment, as well as their association with prognosis. METHODS: A...

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Identifiers

PMID: 37261522
DOI: 10.1007/s00432-023-04924-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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