Article

ARCADIA Reveals Spatially Dependent Transcriptional Programs through Integration of scRNA-seq and Spatial Proteomics

2025-11-21

Abstract excerpt

<h4>Motivation</h4> Cellular states are strongly influenced by spatial context, but single-cell RNA sequencing (scRNA-seq) loses information about local tissue organization, while spatial proteomic assays capture limited marker panels that constrain transcriptomic inference. Integrating these modalities can elucidate how spatial niches shape transcriptional programs, yet existing approaches depend on either featu...

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Literature Corpus work: 3c03c3a8-431f-54c3-a8be-f36915e696b5
DOI: 10.1101/2025.11.20.689521

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