Article

CHAMPOLLION: Robust Multi-Omics Integration via Inverse Optimal Transport Using Paired Cells

2026-04-30

Abstract excerpt

Fully capturing cellular identity requires integrating multiple molecular layers. Bridge integration, i.e. aligning unimodal datasets using a paired multi-omic reference, has emerged as a practical solution, yet existing methods offer limited interpretability and use paired information without regularization, making them sensitive to limited size and coverage. We introduce CHAMPOLLION, which uses regularized optim...

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Literature Corpus work: a209fd66-f6dd-5dea-b291-671255f2df38
DOI: 10.64898/2026.04.28.721317

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