Article

Impact of maternal compensation on developmental phenotypes in a zebrafish model of severe congenital muscular dystrophy

2025-05-13

Abstract excerpt

Genetic compensation is a common phenomenon in zebrafish in response to genetic alterations. As such, differences between morphant and mutant zebrafish models of human diseases have led to significant difficulties in phenotypic interpretation and translatability. One form of compensation is the maternal deposit of mRNAs and proteins into the oocyte that supports developmental processes before zygotic genome activa...

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Literature Corpus work: 3bc9b490-110e-53d7-9dab-223c5e52363e
DOI: 10.1101/2025.05.13.653769

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