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Transcriptomic and functional comparison of cells isolated from healthy and degenerated ovine intervertebral discs

2025-11-07

Abstract excerpt

<h4>Structured abstract</h4> <h4>Background</h4> Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain and disability. Understanding the cellular and molecular mechanisms underlying disc degeneration is crucial for developing effective therapies. Sheep have emerged as a promising large-animal model for IVDD research due to their similarities with humans. They exhibit resembling spin...

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Literature Corpus work
8956919f-46df-502d-a392-e666ef534007
DOI
10.1101/2025.11.06.686904
Open publication

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Transcriptomic and functional comparison of cells isolated from healthy and degenerated ovine intervertebral discsDOI 10.1101/2025.11.06.686904
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