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Article

IGF-1 rescues human intervertebral annulus cells from<i>in vitro</i>stress-induced premature senescence

1 Jan 2008

Abstract excerpt

The aging human intervertebral disc contains a sizeable population of senescent cells. Since senescent cells cannot divide, senescence reduces the disc's ability to generate new cells to replace existing ones lost to necrosis or apoptosis. The objectives of the present work were: (1) to develop a reliable in vitro model for stress-induced premature senescence in human annulus cells, and (2) to investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19021034
DOI: 10.1080/08977190802273814

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