Article

<i>E. coli</i> phylogeny drives co-amoxiclav resistance through variable expression of <i>bla</i> <sub>TEM-1</sub>

2024-08-12

Abstract excerpt

Co-amoxiclav resistance in E. coli is a clinically important phenotype associated with increased mortality. The class A beta-lactamase bla TEM-1 is often carried by co- amoxiclav-resistant pathogens, but exhibits high phenotypic heterogeneity, making genotype-phenotype predictions challenging. We present a curated dataset of n =377 E. coli isolates representing all 8 known phylogroups, where the only acquired...

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Literature Corpus work: 3b0aa369-483b-5fb0-aacd-b500b8e9a5d8
DOI: 10.1101/2024.08.12.607562

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