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Reconciling the Potentially Irreconcilable? Genotypic and Phenotypic Amoxicillin-Clavulanate Resistance in Escherichia coli.

Antimicrobial agents and chemotherapy - 21 May 2020

Davies Timothy J, Stoesser Nicole, Sheppard Anna E, Abuoun Manal, Fowler Philip, Swann Jeremy, Quan T Phuong, Griffiths David, Vaughan Alison, Morgan Marcus, Phan Hang T T, Jeffery Katie J, Andersson Monique, Ellington Matt J, Ekelund Oskar, Woodford Neil, Mathers Amy J, Bonomo Robert A, Crook Derrick W, Peto Tim E A, Anjum Muna F, Walker A Sarah

Abstract excerpt

Resistance to amoxicillin-clavulanate, a widely used beta-lactam/beta-lactamase inhibitor combination antibiotic, is rising globally, and yet susceptibility testing remains challenging. To test whether whole-genome sequencing (WGS) could provide a more reliable assessment of susceptibility than traditional methods, we predicted resistance from WGS for 976 Escherichia coli bloodstream infection isolates from...

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PMID: 32205351
DOI: 10.1128/AAC.02026-19
PMCID: PMC7269502

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