Article

Characterization of ATP hydrolysis in the Hsp70 BiP nucleotide binding domain

2024-03-07

Abstract excerpt

<title>Abstract</title> <p><bold>The 70 kDa heat shock protein (Hsp70) family of molecular chaperones is crucial for protein biogenesis and homeostasis in all kingdoms of life. Hsp70 activity is driven by ATP hydrolysis in the nucleotide binding domain (NBD).</bold> <bold>Here, we report an experimental setup to resolve the functional cycle of Hsp70 in unprecedented spatial and temporal resolution. The method com...

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Literature Corpus work: 3afa3d88-05b6-57ee-8c0c-21b9a1acca16
DOI: 10.21203/rs.3.rs-4017836/v1

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