Article
Two closed ATP- and ADP-dependent conformations in yeast Hsp90 chaperone detected by Mn(II) EPR spectroscopic techniques.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2020
Giannoulis Angeliki, Feintuch Akiva, Barak Yoav, Mazal Hisham, Albeck Shira, Unger Tamar, Yang Feng, Su Xun-Cheng, Goldfarb Daniella
Abstract excerpt
Hsp90 plays a central role in cell homeostasis by assisting folding and maturation of a large variety of clients. It is a homo-dimer, which functions via hydrolysis of ATP-coupled to conformational changes. Hsp90's conformational cycle in the absence of cochaperones is currently postulated as apo-Hsp90 being an ensemble of "open"/"closed" conformations. Upon ATP binding, Hsp90 adopts an active ATP-bound closed...
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