Article

Regulation of brain development by the Minibrain/Rala signaling network

2024-05-12

Abstract excerpt

The human dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) is implicated in the pathology of Down syndrome, microcephaly, and cancer, however the exact mechanism through which it functions is unknown. Here, we have studied the role of the Drosophila ortholog of DYRK1A, Minibrain (Mnb), in brain development. The neuroblasts (neural stem cells) that eventually give rise to differentiated neuro...

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Literature Corpus work: 3ae6659c-2dc0-5921-8f1c-ae056a16e6f3
DOI: 10.1101/2024.05.10.593605

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