Article

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

2019-03-31

Abstract excerpt

Analyzing 5770 all-cause cirrhosis cases and 572,850 controls from seven cohorts, we identify a missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene ( MARC1 p.A165T) that associates with protection from all-cause cirrhosis (OR 0.88, p=2.1*10 −8 ). This same variant also associates with lower levels of hepatic fat on computed tomographic imaging and lower odds of physician-diagnosed fatty liv...

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Literature Corpus work: 3abf0fa4-301c-5b20-93e1-0433dea94966
DOI: 10.1101/594523

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