Article

AAV-mediated MUC5AC siRNA delivery to prevent mucociliary dysfunction in asthma

2025-03-14

Abstract excerpt

The main structural components of mucus produced in the lung are mucin 5B (MUC5B) and mucin 5AC (MUC5AC) where a relatively higher expression of MUC5B is typical in health. In the lungs of individuals with asthma, there is a shift from MUC5B to MUC5AC as the predominantly secreted mucin which has been shown to impair mucociliary clearance (MCC) and increase mucus plug formation in the airways. Given its role in as...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3aa75dd8-d0a8-5fcf-bb37-0aa62f1bd0b0
DOI: 10.1101/2025.03.12.642720

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AAV-mediated MUC5AC siRNA delivery to prevent mucociliary dysfunction in asthmaDOI 10.1101/2025.03.12.642720Read

AAV-mediated MUC5AC siRNA delivery to prevent mucociliary dysfunction in asthmaSemantic proximity Read

An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene TherapySemantic proximity Read

Extracellular vesicles enhance pulmonary transduction of stably associated adeno‐associated virus following intratracheal administrationSemantic proximity Read

Inhaled gene therapy of preclinical muco-obstructive lung diseases by nanoparticles capable of breaching the airway mucus barrierSemantic proximity Read

Dysregulation of MUC5B and MUC5AC alters granulocyte frequency and activation in the lung and distal sitesSemantic proximity Read

Modeling Pulmonary Disease Pathways Using Recombinant Adeno-Associated Virus 6.2Semantic proximity Read

Transduction Efficiencies of Novel AAV Vectors in Mouse Airway Epithelium In Vivo and Human Ciliated Airway Epithelium In VitroSemantic proximity Read

A lentiviral toolkit to monitor airway epithelial cell differentiation using bioluminescenceSemantic proximity Read

Recent Advances in Therapeutics and Manufacturing Processes of Recombinant Adeno-Associated Virus for the Treatment of Lung DiseasesSemantic proximity Read

Muc5b is required for airway defenceSemantic proximity Read

Lentiviral Gene Delivery Rescues Ciliary Defects in Patient-Derived Airway Organoids from Primary Ciliary Dyskinesia.Semantic proximity Read

Central Role of Muc5ac Expression in Mucous Metaplasia and Its Regulation by Conserved 5′ ElementsSemantic proximity Read