Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling Pulmonary Disease Pathways Using Recombinant Adeno-Associated Virus 6.2

6 Apr 2015

Abstract excerpt

Viral vectors have been applied successfully to generate disease-related animal models and to functionally characterize target genes in vivo. However, broader application is still limited by complex vector production, biosafety requirements, and vector-mediated immunogenic responses, possibly interfering with disease-relevant pathways. Here, we describe adeno-associated virus (AAV) variant 6.2 as an ideal vector...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Plant Virus Research Studies
Share to Respiratory viral infections research
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25845025
DOI: 10.1165/rcmb.2014-0338ma

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling Pulmonary Disease Pathways Using Recombinant Adeno-Associated Virus 6.2PMID 25845025Read ↗

Cross-species tropism of AAV.CPP.16 in the respiratory tract and its gene therapies against pulmonary fibrosis and viral infectionSemantic proximity Read ↗

Characterization of a flexible AAV-DTR/DT mouse model of acute epithelial lung injurySemantic proximity Read ↗

Time and phenotype-dependent transcriptome analysis in AAV-TGFβ1 and Bleomycin-induced lung fibrosis models.Semantic proximity Read ↗

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathologySemantic proximity Read ↗

Recent Advances in Therapeutics and Manufacturing Processes of Recombinant Adeno-Associated Virus for the Treatment of Lung DiseasesSemantic proximity Read ↗

A humanized mouse model of chronic COVID-19 to evaluate disease mechanisms and treatment optionsSemantic proximity Read ↗

ACE2 is the critical <i>in vivo</i> receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathologySemantic proximity Read ↗

A Novel Triple-Mutant AAV6 Capsid Induces Rapid and Potent Transgene Expression in the Muscle and Respiratory Tract of MiceSemantic proximity Read ↗

SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signalingSemantic proximity Read ↗

Novel Insights into the Therapeutic Potential of Lung-Targeted Gene Transfer in the Most Common Respiratory DiseasesSemantic proximity Read ↗

Tropism of AAV.CPP.16 in the respiratory tract and its application for a CRISPR-based gene therapy against SARS-CoV-2Semantic proximity Read ↗

SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.