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Article

Expanding the chemical space of anti-HCV NS5A inhibitors by stereochemical exchange and peptidomimetic approaches.

Archiv der Pharmazie - 1 Jul 2018

Ramsis Triveena M, Abdel Karim Shereen E, Vassilaki Niki, Frakolaki Efseveia, Kamal Ahmed A M, Zoidis Grigoris, Ahmed Nermin S, Abadi Ashraf H

Abstract excerpt

Here we report a series of potent anti-HCV agents bearing a symmetrical benzidine l-prolinamide backbone with different capping groups including alkyl/aryl carbamates of natural and unnatural valine and leucine amino acids. All compounds were investigated for their inhibitory activity in an HCV replicon assay on genotype 1b. The novel compounds share some chemical and clinical attributes of commercially available...

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Identifiers

PMID: 29799645
DOI: 10.1002/ardp.201800017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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