Detection and quantification of GPCR mRNA: An assessment and implications of data from high-content methods

Abstract excerpt

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors and targets for approved drugs. Analysis of GPCR expression is thus important for drug discovery and typically involves mRNA-based methods. We compared transcriptomic cDNA [Affymetrix] microarrays, RNA-seq and qPCR-based TaqMan arrays for their ability to detect and quantify expression of endoGPCRs (non-chemosensory GPCRs with endogen...

Topics

Open a Topic to create a Post that cites this publication.

• Autoimmune Diseases
• Cholesterol and Lipid Metabolism
• Gene Expression Profiling
• Mass Spectrometry Techniques and Applications
• Monoclonal and Polyclonal Antibodies Research
• Neuropeptides and Animal Physiology
• Oligonucleotide Array Sequence Analysis
• Receptor Mechanisms and Signaling

Identifiers and source

Literature Corpus work

3a5773b1-775f-576f-a675-034fd263f2ef

DOI

10.1101/734863