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Protective effect of increased O-GlcNAc cycling against 6-OHDA induced Parkinson's disease pathology

2024-02-07

Abstract excerpt

<title>Abstract</title> <p>This study aimed to elucidate the role of <italic>O</italic>-GlcNAc cycling in 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease (PD)-like neurodegeneration and the underlying mechanisms. We observed dose-dependent downregulation of <italic>O</italic>-GlcNAcylation, accompanied by an increase in <italic>O</italic>-GlcNAcase following 6-OHDA treatment in both mouse brain and Neuro2a...

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Literature Corpus work
3a4ad369-77e2-58b8-a0cc-7b3c2c0d2b3d
DOI
10.21203/rs.3.rs-3825103/v1
Open publication

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