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A novel computational pipeline for <i>var</i> gene expression augments the discovery of changes in the <i>Plasmodium falciparum</i> transcriptome during transition from <i>in vivo</i> to short-term <i>in vitro</i> culture

2023-03-24

Abstract excerpt

The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the highly polymorphic family of var genes, the sequences of which are largely unknown in clinical samples. Previously, we published new approaches for var gene profiling and classif...

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Literature Corpus work
3a447368-1860-5587-8535-e2d54d74056c
DOI
10.1101/2023.03.21.533599
Open publication

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A novel computational pipeline for <i>var</i> gene expression augments the discovery of changes in the <i>Plasmodium falciparum</i> transcriptome during transition from <i>in vivo</i> to short-term <i>in vitro</i> cultureDOI 10.1101/2023.03.21.533599
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