Article

Phosphate and acidosis cause fiber-type specific changes to cellular and molecular contractile mechanics at 37°C in skeletal muscle from older adults

2025-09-03

Abstract excerpt

<h4>ABSTRACT</h4> Intracellular accumulation of hydrogen ions (H + ) and inorganic phosphate (P i ) have temperature-dependent effects on single fiber contractile function between 10-30°C. In vivo , human skeletal muscle temperatures range between 35-38°C, and although contractile function is highly dependent on temperature, the effects of fatigue-inducing [H + ] and [P i ] on contractile mechanics at 37°C i...

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Literature Corpus work: 3a3f6ea2-f4db-50a0-97d0-d803992337b7
DOI: 10.1101/2025.08.28.672942

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